Current Funded Project

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The Meghan Rose Bradley Foundation currently supports research being pursued by Dr. Winson Ho, Associate Professor of Neurosurgery at UC San Francisco. The objective of his work is to test a novel potential treatment for medulloblastoma, which is the most common malignant brain tumor in children. The experiments involve identifying whether a drug already in phase II clinical trials for a separate purpose cause the tumor cells to stop dividing. This will slow or even possibly prevent tumor growth. While this would be very helpful, it wouldn’t eliminate the tumor and it is possible that the cells will continue to adapt and find a way to start growing again. Therefore, he will couple this treatment with immunotherapy by using killer T cells to target the cells that have been treated by the drug. In this way, the drug acts both as a brake on tumor growth and a beacon for the T cells to properly identify which cells to eliminate. If successful, this treatment will enable a cure for medulloblastoma that does not require surgery and may reduce or eliminate surgery and chemotherapy as well.